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Undulating changes in human plasma proteome profiles across the lifespan
Lehailler, B., D., Schaum, N. et al.
Nat Med 25, 1843-1850
Disease Biology
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
Sabatine, MS
JAMA 315(23): 2525-2526.
Cardiovascular targetidentification diagnostics
Plasma proteome in multiple sclerosis disease progression
Malekzadeh A, et al.
Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594.
diseasebiology Neurobiology diagnostics
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease
Pierson, SK et al.
Am J Hematol 93(7): 902-912.
diseasebiology Inflammatory Rare diagnostics
Molecular-based diagnosis of multiple sclerosis and its progressive stage
Barbour, C et al.
Ann Neurol 82(5): 795-812.
diseasebiology Neurobiology diagnostics
Vitamin B12 deficiency and impaired expression of amnionless during aging
Pannerec, A et al.
J Cachexia Sarcopenia Muscle 9(1): 41-52.
diseasebiology Aging
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies
Spitali, P et al.
J Cachexia Sarcopenia Muscle 9(4): 715-726.
diseasebiology Pediatric Musculoskeletal diagnostics
Serum proteomic assessment of the progression of fracture healing
Hussein, AI et al.
J Orthop Res 36(4): 1153-1163.
Osteoporosis diagnostics
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Wu, D et al.
Laryngoscope 129(3): E102-E109.
diseasebiology Exosomes Osteoporosis
Vero cell proteomic changes induced by Zika virus infection
Glover, KKM et al.
Proteomics 19(4): e1800309.
diseasebiology Neurobiology Infection
Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery
McArdle, A et al.
Proteomics Clin Appl 10(6): 691-698.
diseasebiology Immunity diagnostics
Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis
DeBoer, EM et al.
Proteomics Clin Appl 11(9-10).
diseasebiology Respiratory Pediatric diagnostics
The impact of the glomerular filtration rate on the human plasma proteome
Christensson, A et al.
Proteomics Clin Appl 12(3): e1700067.
diseasebiology Kidney diagnostics
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid
DeBoer, EM et al.
Proteomics Clin Appl: e1800085.
diseasebiology Rare diagnostics
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Simats A, et al.
Methods Mol Biol. 2044:221-231.
diseasebiology Neurobiology
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Hok-A-Hin YS, et al.
Methods Mol Biol. 2044:27-50.
diseasebiology Large-scale-proteomics Neurobiology SomaScan
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Liang, X et al.
Calcif Tissue Int 104(2): 171-181.
diseasebiology Osteoporosis targetidentification diagnostics
SELEX: How it happened and where it will go
Gold, L
J Mol Evol 81(5-6): 140-143.
Reviews
Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy
Anderson, J et al.
Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular Pediatric Neurobiology diagnostics
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla CM, et al.
Obes Surg. 2019 Jul;29(7):2092-2099.
diseasebiology Metabolic
Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study
Monteiro, JP et al.
Genes Nutr 9(3): 403.
diseasebiology Metabolic diagnostics
Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Morine, MJ et al.
Genes Nutr 9(4): 408.
diseasebiology Metabolic
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
Shimada YJ, et al.
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579.
diseasebiology Cardiovascular diagnostics
Let's get specific: the relationship between specificity and affinity
Eaton, BE et al.
Chem Biol 2(10): 633-638.
Binding SomaScan
The relationship of circulating proteins in early pregnancy with preterm birth
Lynch, AM et al.
Am J Obstet Gynecol 214(4): 517 e511-518.
diseasebiology Reproductive diagnostics
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study
Romero, R et al.
Am J Obstet Gynecol 217(1):67 e61-67 e21.
diseasebiology Reproductive diagnostics
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
Baird, GS et al.
Am J Pathol 180(2): 446-456.
diseasebiology Aging Neurobiology diagnostics
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform
Qiao, Z et al.
Biochim Biophys Acta 1865(4): 434-443.
diseasebiology Oncology diagnostics
Proteomics and diagnostics: Let's get specific, again
Zichi, D et al.
Curr Opin Chem Biol 12(1): 78-85.
SomaScan
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Loffredo, FS et al.
Cell 153(4): 828-839.
diseasebiology Cardiovascular diagnostics
Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea
Jung, YJ et al.
Clin Lung Cancer 18(2): e99-e107.
Oncology diagnostics
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers
Ochsner, UA et al.
Diagn Microbiol Infect Dis 76(3): 278-285.
Infection diagnostics
Benefit of apabetalone on plasma proteins in renal disease
Wasiak, S et al.
Kidney International Reports 3(3): 711-721.
diseasebiology Kidney mechanismofaction diagnostics
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients
Yu, LR et al.
Kidney Int Rep 3(5): 1202-1213.
diseasebiology Kidney targetidentification diagnostics
Scanning into the future: the promise of SOMAScan technology for kidney disease
Coca, SG
Kidney Int Rep 3(5): 1020-1022.
diseasebiology Kidney diagnostics
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia
Giudice, V et al.
Exp Hematol 68: 38-50.
diseasebiology Rare diagnostics
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents
Katilius E et al.
Forensic Sci Int Genet 35: 9-13.
Binding SomaScan
Cancer protein biomarker discovery based on nucleic acid aptamers
Xiong H, et al.
Int J Biol Macromol. 2019 Jul 1;132:190-202.
diseasebiology Oncology diagnostics
Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome
Nishikawa, A et al.
Arthritis Res Ther 18(1): 106.
diseasebiology Immunity targetidentification diagnostics
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma
Rossios, C et al.
J Allergy Clin Immunol 141(2): 560-570.
diseasebiology Respiratory diagnostics
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
Nocera, AL et al.
J Allergy Clin Immunol 143(4):1525-1535 e1521.
diseasebiology Exosomes
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
Leonard A, et al.
J Allergy Clin Immunol Pract. pii: S2213-2198(19)30719-6.
diseasebiology Inflammatory diagnostics
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Sattlecker, M et al.
Alzheimers Dement 10(6): 724-734.
diseasebiology Aging diagnostics
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Shi L, et al.
Alzheimers Dement. 5. pii: S1552-5260(19)35118-0.
diseasebiology Aging diagnostics
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells
Jin, P et al.
Cytotherapy 20(5): 728-739.
Oncology mechanismofaction diagnostics
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
Vilar-Gomez, E et al.
J Hepatol 68(2): 305-315.
diseasebiology Inflammatory Fibrotic Metabolic diagnostics
A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin
Rice, LM et al.
J Invest Dermatol 137(1): 62-70.
diseasebiology Immunity diagnostics
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
Foulkes, AC et al.
J Invest Dermatol 139(1): 100-107.
diseasebiology Immunity stratification diagnostics
Life's simple measures: unlocking the proteome
Brody, E et al.
J Mol Biol 422(5):595-606.
Reviews
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Masvekar, R et al.
Mult Scler Relat Disord 28: 34-43.
diseasebiology Neurobiology diagnostics
A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)
Petek, LM et al.
Neuromuscul Disord 26(7): 405-413.
diseasebiology Musculoskeletal diagnostics
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
De Groote, MA et al.
PLoS One 8(4): e61002.
diseasebiology Infection diagnostics
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
Conklin, LS et al.
Pharmacol Res 136: 140-150.
diseasebiology Neurobiology pkpd stratification diagnostics
Embracing proteins: structural themes in aptamer-protein complexes
Gelinas, AD et al.
Curr Opin Struct Biol 36: 122-132.
Structure SomaScan
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Hathout Y, et al.
Sci Rep. 2019 Aug 21;9(1):12167.
diseasebiology Musculoskeletal diagnostics
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Desai, VG et al.
Toxicol Appl Pharmacol 363:164-173.
Oncology pkpd stratification
Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis
Nahid, P et al.
Tuberculosis (Edinb) 94(3): 187-196.
Infection stratification diagnostics
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases
Deterding RR, et al.
Am J Respir Crit Care Med. doi: 10.1164.
diseasebiology Respiratory Pediatric diagnostics
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
Rhodes, CJ et al.
Lancet Respir Med 5(9): 717-726.
diseasebiology Cardiovascular Respiratory Rare targetidentification
Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
Curran, AM et al.
J Proteome Res 16(11): 4122-4133.
diseasebiology Aging Metabolic
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Bodewes, ILA et al.
Front Immunol 10: 312.
diseasebiology Inflammatory Immunity targetidentification diagnostics
Expanding the chemistry of DNA for in vitro selection
Vaught, JD et al.
J Am Chem Soc 132(12): 4141-4151.
SomaScan
Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease
Heier, CR et al.
Clin Transl Gastroenterol 7(9): e192.
diseasebiology Inflammatory Pediatric mechanismofaction
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Xie, Y et al.
EMBO Rep 14(12): 1120-1126.
diseasebiology Clinical Oncology SomaScan
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism
Thrush, AB et al.
Int J Obes (Lond) 42(3): 353-362.
diseasebiology Metabolic Osteoporosis diagnostics
Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents
Rohloff, JC et al.
Mol Ther Nucleic Acids 3:e201.
Binding Reviews Clinical SomaScan
Connecting genetic risk to disease end points through the human blood plasma proteome
Suhre, K et al.
Nat Commun 8: 14357.
Large-scale-proteomics SomaScan
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Howson, JMM et al.
Nat Genet 49(7): 1113-1119.
diseasebiology Cardiovascular
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
Lukjanenko, L et al.
Nat Med 22(8): 897-905.
diseasebiology Aging Musculoskeletal
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA
Zimmermann, GR et al.
Nat Struct Biol 4(8): 644-649.
Structure SomaScan
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells
Zahedi-Amiri A, et al.
Cell Death Dis. 2019 May; 10(5): 337.
diseasebiology Infection Reproductive
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Carayol, J et al.
Nat Commun 8(1): 2084.
diseasebiology Metabolic diagnostics
Genomic atlas of the human plasma proteome
Sun, BB et al.
Nature 558: 73-79.
Large-scale-proteomics SomaScan
Improving probes for super-resolution
Moore, RP et al.
Nat Methods 15(9): 659-660.
Binding SomaScan
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Sullivan, KD et al.
Sci Rep 7(1): 14818.
diseasebiology Rare
Assessment of variability in the SOMAscan assay
Candia, J et al.
Sci Rep 7(1):14248.
Binding Reviews SomaScan
Divergent roles for clusterin in lung injury and repair
Habiel, DM et al.
Sci Rep 7(1): 15444.
diseasebiology Respiratory Fibrotic
A pilot characterization of the human chronobiome
Skarke, C et al.
Sci Rep 7(1):17141.
diseasebiology Metabolic
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform
Kim, CH et al.
Sci Rep 8(1): 8382.
Binding Reviews SomaScan
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar, B et al.
Sci Rep 8(1): 14915.
diseasebiology Inflammatory diagnostics
Increased cerebrospinal fluid fibrinogen in major depressive disorder
Hattori, K et al.
Sci Rep 5: 11412.
diseasebiology Neurobiology
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children
Hathout, Y et al.
Sci Rep 6: 31727.
diseasebiology Inflammatory Pediatric diagnostics
Identification of serum protein biomarkers for utrophin based DMD therapy
Guiraud, S et al.
Sci Rep 7: 43697.
diseasebiology Pediatric Musculoskeletal diagnostics
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Davies, DR et al.
Proc Natl Acad Sci U S A 109(49): 19971-19976.
Structure SomaScan
Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy
Hathout, Y et al.
Proc Natl Acad Sci U S A 112(23): 7153-7158.
diseasebiology Pediatric Musculoskeletal targetidentification diagnostics
Selection of DNA aptamers with two modified bases
Gawande, BN et al.
Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Depner CM et al.
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
diseasebiology Metabolic
Classification of prostate cancer using a protease activity nanosensor library
Dudani, JS et al.
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Oncology diagnostics
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand
Gelinas, AD et al.
J Biol Chem 289(12): 8720-8734.
Structure SomaScan
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform
Webber, J et al.
Mol Cell Proteomics 13(4): 1050-1064.
Oncology Exosomes diagnostics
Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents
Rohloff, JC et al.
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
SomaScan
Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys
Hirota, M et al.
Nucleic Acid Ther 26(1): 10-19.
diseasebiology Immunity targetidentification targetidentification mechanismofaction
Fit for the eye: aptamers in ocular disorders
Drolet, DW et al.
Nucleic Acid Ther 26(3): 127-146.
diseasebiology Ocular targetidentification mechanismofaction pkpd diagnostics
Pharmacokinetic properties of DNA aptamers with base modifications
Gupta, S et al.
Nucleic Acid Ther 27(6): 345-353.
Binding SomaScan
Circulating proteomic signatures of chronological age
Menni, C et al.
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
diseasebiology Aging diagnostics
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome
Sasayama, D et al.
Hum Mol Genet 26(1): 44-51.
diseasebiology Neurobiology diagnostics
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Zaghlool, SB et al.
Hum Mol Genet 27(6): 1106-1121.
diseasebiology Respiratory Metabolic
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
Wolk, SK et al.
Nucleic Acids Res 43(19): 9107-9122.
SomaScan
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis
Wermuth, PJ et al.
Rheumatology (Oxford) 57(10): 1698-1706.
diseasebiology Immunity diagnostics
readat: an R package for reading and working with SomaLogic ADAT files
Cotton, RJ et al.
BMC Bioinformatics 17(1): 201.
Rapid histochemistry using slow off-rate modified aptamers with anionic competition
Gupta, S et al.
Appl Immunohistochem Mol Morphol 19(3): 273-278.
Binding SomaScan
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Fong TG, et al.
Ann Surg. 2019 Mar 26. doi: 10.1097.
diseasebiology Aging Inflammatory
Aptamers and the RNA world, past and present
Gold, L et al.
Cold Spring Harb Perspect Biol 4(3).
Reviews
Plasma proteomic signature of age in healthy humans
Tanaka, T et al.
Aging Cell 17(5): e12799.
Aging diagnostics
A serum protein signature of APOE genotypes in centenarians
Sebastiani P, et al.
Aging Cell. :e13023. doi: 10.1111.
diseasebiology Aging diagnostics
Identification of unique proteomic signatures in allergic and non-allergic skin disease
Wang, J et al.
Clin Exp Allergy 47(11): 1456-1467.
diseasebiology Inflammatory diagnostics
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes
Halama, A et al.
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
diseasebiology Metabolic diagnostics
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components
Baumstummler, A et al.
Lett Appl Microbiol 59(4): 422-431.
Infection diagnostics
Co-regulatory networks of human serum proteins link genetics to disease
Emilsson, V et al.
Science 361(6404): 769-773.
diseasebiology Aging diagnostics
An immune clock of human pregnancy
Aghaeepour, N et al.
Sci Immunol 2(15):eaan2946.
diseasebiology Immunity Reproductive
A degradation fragment of type X collagen is a real-time marker for bone growth velocity
Coghlan, RF et al.
Sci Transl Med 9(419): eaan4669.
diseasebiology Osteoporosis diagnostics
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia
Lertudomphonwanit, C et al.
Sci Transl Med 9(417): eaan8462.
diseasebiology Pediatric targetidentification diagnostics
Activin type II receptor signaling in cardiac aging and heart failure
Roh, JD et al.
Sci Transl Med 11(482).
diseasebiology Aging diagnostics
Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome
Tasaki, S et al.
Ann Rheum Dis 76(8): 1458-1466.
diseasebiology Immunity targetidentification
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial
Ali A et al.
BMJ Open Gastro 4(1): e000164.
diseasebiology Inflammatory
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
Grover M, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
diseasebiology Binding Immunity Metabolic SomaScan diagnostics
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan
Santos-Parker, JR et al.
J Appl Physiol (1985) 125(5): 1646-1659.
diseasebiology Aging diagnostics
Improved preparation of 2 M triethylammonium bicarbonate
Carlson, M et al.
Green Chem Lett Rev 8(3-4): 37-39.
SomaScan
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Ngo, D et al.
Circulation 134(4): 270-285.
Cardiovascular diagnostics
Application of large scale aptamer-based proteomic profiling to planned myocardial infarctions
Jacob, J et al.
Circulation 137(12): 1270-1277.
diseasebiology Cardiovascular targetidentification diagnostics
Genetic architecture of the cardiovascular risk proteome
Benson, MD et al.
Circulation 137(11): 1158-1172.
diseasebiology Cardiovascular targetidentification diagnostics
Integrative omics: harnessing the proteome to maximize the potential of the genome
McGarrah, RW et al.
Circulation 137(11): 1173-1175.
diseasebiology Cardiovascular
Harnessing the power of proteomics to assess drug safety and guide clinical trials
Lam, MPY et al.
Circulation 137(10): 1011-1014.
Cardiovascular stratification
Probing the virtual proteome to identify novel disease biomarkers
Mosley, JD et al.
Circulation 138(22): 2469-2481.
diseasebiology Cardiovascular diagnostics
Cerebrospinal fluid protein changes in preeclampsia
Ciampa, E et al.
Hypertension 72(1): 219-226.
diseasebiology Reproductive
Endothelial microparticles and systemic complement activation in patients with chronic kidney disease
Jalal, D et al.
J Am Heart Assoc 7(14): e007818.
diseasebiology Kidney Inflammatory
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study
Ko, D et al.
J Am Heart Assoc 8(6): e010976.
diseasebiology Cardiovascular diagnostics
Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants
Wagner, BD et al.
Am J Respir Crit Care Med 197(3): 394-397.
diseasebiology Cardiovascular Pediatric
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening
Forster, K et al.
Am J Respir Crit Care Med 197(8): 1076-1080.
diseasebiology Respiratory diagnostics
The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity
Lynch, AM et al.
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
diseasebiology Pediatric diagnostics
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology
Lynch, AM et al.
Transl Vis Sci Technol 8(1): 14.
diseasebiology Aging Ocular diagnostics
Human PAH is characterized by a pattern of lipid-related insulin resistance
Hemnes, AR et al.
JCI Insight 4(1).
diseasebiology Respiratory Metabolic mechanismofaction diagnostics
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
Spitsin, S et al.
JCI Insight. 2017 Oct 5;2(19). pii: 95893.
diseasebiology Immunity Infection mechanismofaction
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state
King, JD et al.
Cartilage. 2018 Jul 1:1947603518790009.
diseasebiology Inflammatory diagnostics
Validation of a blood protein signature for non-small cell lung cancer
Mehan, MR et al.
Clin Proteomics 11(1): 32.
Oncology diagnostics
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Rice, LM et al.
Arthritis Res Ther 20(1): 185.
diseasebiology Respiratory diagnostics
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Tsujikawa LM, et al.
Clin Epigenetics. 2019; 11: 102.
Cardiovascular mechanismofaction stratification diagnostics
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood, S et al.
Alzheimers Res Ther 9(1): 31.
diseasebiology Aging Metabolic
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
Huang G, et al.
The Journal of Clinical Endocrinology and Metabolism 104(9): 3768-3778. https://doi.org/10.1210/jc.2019-00505.
High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors
Di Narzo, AF et al.
PLoS Genet 13(1): e1006565.
diseasebiology Aging Inflammatory
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
Penn-Nicholson A, et al.
PLoS Med. 2019 Apr; 16(4): e1002781.
diseasebiology Infection diagnostics
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer
Ostroff, RM et al.
PLoS One 5(12): e15003.
diseasebiology Oncology diagnostics
Aptamer-based multiplexed proteomic technology for biomarker discovery
Gold, L et al.
PLoS One 5(12): e15004.
Reviews
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer
Mysona, D et al.
Gynecol Oncol 152(3):574-580.
diseasebiology Oncology mechanismofaction diagnostics
High-resolution molecular discrimination by RNA
Jenison, RD et al.
Science 263(5152): 1425-1429.
Reviews
The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention
Oller Moreno, S et al.
Proteomics Clin Appl 12(1).
diseasebiology Metabolic diagnostics
Respiratory mucosal proteome quantification in human influenza infections
Marion, T et al.
PLoS One 11(4): e0153674.
diseasebiology Infection
Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF
Ashley, SL et al.
PLoS One 11(8): e0159878.
diseasebiology Respiratory Fibrotic diagnostics
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
Erez, O et al.
PLoS One 12(7): e0181468.
diseasebiology Reproductive diagnostics
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy
Parolo, S et al.
PLoS One 13(3): e0194225.
diseasebiology Neurobiology diagnostics
A proteomic signature that reflects pancreatic beta-cell function
Curran, AM et al.
PLoS One 13(8): e0202727.
diseasebiology Metabolic diagnostics
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study
Dubin, RF et al.
PLoS One 13(12): e0208042.
diseasebiology Cardiovascular Kidney targetidentification diagnostics
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay
Tin, A et al.
J Appl Lab Med. 2019 Jul;4(1):30-39.
Cardiovascular diagnostics
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease
Oak, P et al.
EMBO Mol Med 9(11): 1504-1520.
diseasebiology Respiratory diagnostics
GDF15 is a heart-derived hormone that regulates body growth
Wang, T et al.
EMBO Mol Med 9(8): 1150-1164.
diseasebiology Cardiovascular Pediatric
High-content affinity-based proteomics: unlocking protein biomarker discovery
Brody, EN et al.
Expert Rev Mol Diagn 10(8): 1013-1022.
Reviews
Diagnosis and prognosis-review of biomarkers for mesothelioma
Sun, HH et al.
Ann Transl Med 5(11): 244.
diseasebiology Respiratory diagnostics
Systematic selection of modified aptamer pairs for diagnostic sandwich assays
Ochsner, UA et al.
Biotechniques 56(3): 125-128, 130, 132-133.
Binding Cardiovascular Infection SomaScan diagnostics
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Gordin D, et al.
Diabetes Care. 2019 Jul;42(7):1263-1273.
diseasebiology Kidney Metabolic diagnostics
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
Kiddle, SJ et al.
J Alzheimers Dis 38(3): 515-531.
diseasebiology Aging stratification diagnostics
Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease
Sattlecker, M et al.
J Alzheimers Dis 49(4): 1105-1114.
diseasebiology Aging targetidentification
Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition
Wang, X et al.
Haematologica 103(3): 466-476.
diseasebiology Oncology mechanismofaction
Clinical validation of a protein biomarker panel for non-small cell lung cancer
Jung, YJ et al.
J Korean Med Sci 33(53): e342.
diseasebiology Oncology diagnostics
Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy
Fitzgibbons, TP et al.
Frontiers in Cardiovascular Medicine 4: 49.
diseasebiology Cardiovascular diagnostics
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways
Bar-Or D, e tal.
Front Med (Lausanne). 2019; 6: 54.
diseasebiology Neurobiology Metabolic
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance
Sher et al.
Front Microbiol. 2019 Mar 26;10:596.
diseasebiology Neurobiology Infection
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
Suhre K, et al.
Metabolites 9(7), 122. https://doi.org/10.3390/metabo9070122.
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Yao, C et al.
Nat Commun 9(1): 3268.
diseasebiology Cardiovascular targetidentification diagnostics
An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein
Gupta, V et al.
Bioanalysis 8(15): 1557-1564.
Binding SomaScan
Protein signature of lung cancer tissues
Mehan, MR et al.
PLoS One 7(4): e35157.
diseasebiology Oncology targetidentification diagnostics
Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis
De Groote, MA et al.
J Clin Microbiol 55(10): 3057-3071.
Infection diagnostics
Plasma protein patterns as comprehensive indicators of health
Williams SA, et al.
Nat Med. Dec;25(12):1851-1857.
Binding
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Alexaki A, et al.
Sci Rep. 2019 Oct 29;9(1):15449.
Binding Large-scale-proteomics SomaScan
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers
Ochsner UA, et al.
Biochemistry. 2019 Nov 19;58(46):4632-4640.
Binding SomaScan
Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics
Almufleh A, et al.
Clin Transplant. 2019 Dec 9:e13765.
diseasebiology Cardiovascular diagnostics
Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
Coombs KM, et al.
Viruses 2019, 11(11), 1028.
diseasebiology Infection diagnostics
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
Finkemagel F, et al.
Theranostics. 2019 Aug 22;9(22):6601-6617.
diseasebiology Oncology stratification diagnostics