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Undulating changes in human plasma proteome profiles across the lifespan
Nat Med 25, 1843-1850
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
JAMA 315(23): 2532-2541.
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
JAMA 315(23): 2525-2526.
Plasma proteome in multiple sclerosis disease progression
Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594.
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease
Am J Hematol 93(7): 902-912.
Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps
Int Forum Allergy Rhinol 8(12): 1438-1444.
Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps
Int Forum Allergy Rhinol 9(2): 177-186.
Molecular-based diagnosis of multiple sclerosis and its progressive stage
Ann Neurol 82(5): 795-812.
Vitamin B12 deficiency and impaired expression of amnionless during aging
J Cachexia Sarcopenia Muscle 9(1): 41-52.
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Serum proteomic assessment of the progression of fracture healing
J Orthop Res 36(4): 1153-1163.
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Laryngoscope 129(3): E102-E109.
Vero cell proteomic changes induced by Zika virus infection
Proteomics 19(4): e1800309.
Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery
Proteomics Clin Appl 10(6): 691-698.
Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis
Proteomics Clin Appl 11(9-10).
The impact of the glomerular filtration rate on the human plasma proteome
Proteomics Clin Appl 12(3): e1700067.
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid
Proteomics Clin Appl: e1800085.
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Methods Mol Biol. 2044:221-231.
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Methods Mol Biol. 2044:27-50.
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Calcif Tissue Int 104(2): 171-181.
SELEX: How it happened and where it will go
J Mol Evol 81(5-6): 140-143.
Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy
Pediatr Cardiol 38(8): 1606-1612.
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma
Cancer Chemother Pharmacol 74(4): 739-750.
Cytokines IL-17, TNF and IFN-gamma alter the expression of antimicrobial peptides and proteins disparately: a targeted proteomics analysis using SOMAscan technology
Vaccines (Basel) 6(3).
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Obes Surg. 2019 Jul;29(7):2092-2099.
Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study
Genes Nutr 9(3): 403.
Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Genes Nutr 9(4): 408.
Downregulation of the complement cascade in vitro, in mice and in patients with cardiovascular disease by the BET protein inhibitor apabetalone (RVX-208)
J Cardiovasc Transl Res, 10(4): 337-347.
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579.
Let's get specific: the relationship between specificity and affinity
Chem Biol 2(10): 633-638.
The relationship of circulating proteins in early pregnancy with preterm birth
Am J Obstet Gynecol 214(4): 517 e511-518.
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study
Am J Obstet Gynecol 217(1):67 e61-67 e21.
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
Am J Pathol 180(2): 446-456.
Potential of high-affinity, Slow Off-Rate Modified Aptamer (SOMAmer) reagents for Mycobacterium tuberculosis proteins as tools for infection models and diagnostic applications
J Clin Microbiol 55(10): 3072-3088.
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform
Biochim Biophys Acta 1865(4): 434-443.
Proteomics and diagnostics: Let's get specific, again
Curr Opin Chem Biol 12(1): 78-85.
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Cell 153(4): 828-839.
Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea
Clin Lung Cancer 18(2): e99-e107.
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis
Cytokine 78: 87-93.
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers
Diagn Microbiol Infect Dis 76(3): 278-285.
Benefit of apabetalone on plasma proteins in renal disease
Kidney International Reports 3(3): 711-721.
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients
Kidney Int Rep 3(5): 1202-1213.
Scanning into the future: the promise of SOMAScan technology for kidney disease
Kidney Int Rep 3(5): 1020-1022.
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia
Exp Hematol 68: 38-50.
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents
Forensic Sci Int Genet 35: 9-13.
Cancer protein biomarker discovery based on nucleic acid aptamers
Int J Biol Macromol. 2019 Jul 1;132:190-202.
Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome
Arthritis Res Ther 18(1): 106.
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma
J Allergy Clin Immunol 141(2): 560-570.
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
J Allergy Clin Immunol Pract. pii: S2213-2198(19)30719-6.
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Alzheimers Dement 10(6): 724-734.
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Alzheimers Dement. 5. pii: S1552-5260(19)35118-0.
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells
Cytotherapy 20(5): 728-739.
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
J Hepatol 68(2): 305-315.
A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin
J Invest Dermatol 137(1): 62-70.
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
J Invest Dermatol 139(1): 100-107.
Life's simple measures: unlocking the proteome
J Mol Biol 422(5):595-606.
Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells
J Proteomics 150: 86-97.
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Mult Scler Relat Disord 28: 34-43.
A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)
Neuromuscul Disord 26(7): 405-413.
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
PLoS One 8(4): e61002.
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
Pharmacol Res 136: 140-150.
Embracing proteins: structural themes in aptamer-protein complexes
Curr Opin Struct Biol 36: 122-132.
Selection of aptamers to Neisseria meningitidis and Streptococcus pneumoniae surface specific proteins and affinity assay using thin film AlN resonators
Sensors and Actuators B: Chemical 246: 591-596.
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis
Steroids 140: 159-166.
Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor
Structure 23(7): 1293-1304.
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Sci Rep. 2019 Aug 21;9(1):12167.
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Toxicol Appl Pharmacol 363:164-173.
Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis
Tuberculosis (Edinb) 94(3): 187-196.
A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study
Urology. 2019 Jul;129:35-42.
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases
Am J Respir Crit Care Med. doi: 10.1164.
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
Lancet Respir Med 5(9): 717-726.
Incorporation of Slow Off-Rate Modified Aptamers reagents in single molecule array assays for cytokine detection with ultrahigh sensitivity
Anal Chem 88(17): 8385-8389.
Development and characterization of an HPV Type-16 specific modified DNA aptamer for the improvement of potency assays
Anal Chem 89(6): 3554-3561.
Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples
Anal Chem 90(8): 5162-5170.
The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes
Sci Rep 7: 46560.
Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
J Proteome Res 16(11): 4122-4133.
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Front Immunol 10: 312.
Expanding the chemistry of DNA for in vitro selection
J Am Chem Soc 132(12): 4141-4151.
Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk
PLoS One 12(8): e0182932.
Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis
Cell Mol Immunol 15(8): 756-767.
Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease
Clin Transl Gastroenterol 7(9): e192.
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
EMBO Rep 14(12): 1120-1126.
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism
Int J Obes (Lond) 42(3): 353-362.
Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents
Mol Ther Nucleic Acids 3:e201.
Connecting genetic risk to disease end points through the human blood plasma proteome
Nat Commun 8: 14357.
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Nat Genet 49(7): 1113-1119.
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
Nat Med 22(8): 897-905.
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA
Nat Struct Biol 4(8): 644-649.
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells
Cell Death Dis. 2019 May; 10(5): 337.
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.
Nat Commun 8(1): 810.
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Nat Commun 8(1): 2084.
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
Nat Commun 9(1): 2755.
Genomic atlas of the human plasma proteome
Nature 558: 73-79.
Strauss, S et al. (2018) “Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
Nat Methods 15(9): 685-688.
Improving probes for super-resolution
Nat Methods 15(9): 659-660.
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Sci Rep 7(1): 14818.
Assessment of variability in the SOMAscan assay
Sci Rep 7(1):14248.
Divergent roles for clusterin in lung injury and repair
Sci Rep 7(1): 15444.
A pilot characterization of the human chronobiome
Sci Rep 7(1):17141.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology
Sci Rep 8(1): 7899.
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform
Sci Rep 8(1): 8382.
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Sci Rep 8(1): 14915.
Increased cerebrospinal fluid fibrinogen in major depressive disorder
Sci Rep 5: 11412.
A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains
Sci Rep 7: 43238.
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
Transl Psychiatry 5: e584.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Proc Natl Acad Sci U S A 109(49): 19971-19976.
Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy
Proc Natl Acad Sci U S A 112(23): 7153-7158.
Selection of DNA aptamers with two modified bases
Proc Natl Acad Sci U S A 114(11): 2898-2903.
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Classification of prostate cancer using a protease activity nanosensor library
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor
J Biol Chem 289(12): 8706-8719.
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand
J Biol Chem 289(12): 8720-8734.
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform
Mol Cell Proteomics 13(4): 1050-1064.
Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys
Nucleic Acid Ther 26(1): 10-19.
Fit for the eye: aptamers in ocular disorders
Nucleic Acid Ther 26(3): 127-146.
Pharmacokinetic properties of DNA aptamers with base modifications
Nucleic Acid Ther 27(6): 345-353.
Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts
Eur Heart J 36(48): 3426-3434.
Circulating proteomic signatures of chronological age
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome
Hum Mol Genet 26(1): 44-51.
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Hum Mol Genet 27(6): 1106-1121.
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
Nucleic Acids Res 43(19): 9107-9122.
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis
Rheumatology (Oxford) 57(10): 1698-1706.
The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling
FASEB J 33(2):2944-2956.
readat: an R package for reading and working with SomaLogic ADAT files
BMC Bioinformatics 17(1): 201.
Rapid histochemistry using slow off-rate modified aptamers with anionic competition
Appl Immunohistochem Mol Morphol 19(3): 273-278.
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Ann Surg. 2019 Mar 26. doi: 10.1097.
Aptamers and the RNA world, past and present
Cold Spring Harb Perspect Biol 4(3).
Plasma proteomic signature of age in healthy humans
Aging Cell 17(5): e12799.
A serum protein signature of APOE genotypes in centenarians
Aging Cell. :e13023. doi: 10.1111.
Identification of unique proteomic signatures in allergic and non-allergic skin disease
Clin Exp Allergy 47(11): 1456-1467.
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components
Lett Appl Microbiol 59(4): 422-431.
Co-regulatory networks of human serum proteins link genetics to disease
Science 361(6404): 769-773.
An immune clock of human pregnancy
Sci Immunol 2(15):eaan2946.
A degradation fragment of type X collagen is a real-time marker for bone growth velocity
Sci Transl Med 9(419): eaan4669.
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia
Sci Transl Med 9(417): eaan8462.
Activin type II receptor signaling in cardiac aging and heart failure
Sci Transl Med 11(482).
Highly multiplexed proteomic analysis of quantiferon supernatants to identify biomarkers of latent tuberculosis infection
J Clin Microbiol 55(2): 391-402.
Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome
Ann Rheum Dis 76(8): 1458-1466.
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial
BMJ Open Gastro 4(1): e000164.
Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma (DIAPHRAGM) study: protocol of a prospective, multicentre, observational study
BMJ Open 6(11): e013324.
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan
J Appl Physiol (1985) 125(5): 1646-1659.
Improved preparation of 2 M triethylammonium bicarbonate
Green Chem Lett Rev 8(3-4): 37-39.
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Circulation 134(4): 270-285.
Identifying low-abundance biomarkers: Aptamer-based proteomics potentially enables more sensitive detection in cardiovascular diseases
Circulation 134(4): 286-289.
Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib
Circulation 137(10): 999-1010.
Application of large scale aptamer-based proteomic profiling to planned myocardial infarctions
Circulation 137(12): 1270-1277.
Genetic architecture of the cardiovascular risk proteome
Circulation 137(11): 1158-1172.
Integrative omics: harnessing the proteome to maximize the potential of the genome
Circulation 137(11): 1173-1175.
Harnessing the power of proteomics to assess drug safety and guide clinical trials
Circulation 137(10): 1011-1014.
Probing the virtual proteome to identify novel disease biomarkers
Circulation 138(22): 2469-2481.
Cerebrospinal fluid protein changes in preeclampsia
Hypertension 72(1): 219-226.
Endothelial microparticles and systemic complement activation in patients with chronic kidney disease
J Am Heart Assoc 7(14): e007818.
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study
J Am Heart Assoc 8(6): e010976.
Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants
Am J Respir Crit Care Med 197(3): 394-397.
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening
Am J Respir Crit Care Med 197(8): 1076-1080.
The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology
Transl Vis Sci Technol 8(1): 14.
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
JCI Insight. 2017 Oct 5;2(19). pii: 95893.
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state
Cartilage. 2018 Jul 1:1947603518790009.
Validation of a blood protein signature for non-small cell lung cancer
Clin Proteomics 11(1): 32.
Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study
Genes Nutr 13: 7.
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Arthritis Res Ther 20(1): 185.
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Clin Epigenetics. 2019; 11: 102.
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Alzheimers Res Ther 9(1): 31.
Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome
Biomark Res 6: 28.
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
The Journal of Clinical Endocrinology and Metabolism 104(9): 3768-3778. https://doi.org/10.1210/jc.2019-00505.
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells
Development 144(6): 1056-1064.
High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors
PLoS Genet 13(1): e1006565.
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
PLoS Med. 2019 Apr; 16(4): e1002781.
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer
PLoS One 5(12): e15003.
Aptamer-based multiplexed proteomic technology for biomarker discovery
PLoS One 5(12): e15004.
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay
PLoS One 6(10): e26332.
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer
Gynecol Oncol 152(3):574-580.
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool
PLoS One 7(10):e46091.
Measurement of cetuximab and panitumumab-unbound serum EGFR extracellular domain using an assay based on slow off-rate modified aptamer (SOMAmer) reagents
PLoS One 8(8): e71703.
High-resolution molecular discrimination by RNA
Science 263(5152): 1425-1429.
The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention
Proteomics Clin Appl 12(1).
Respiratory mucosal proteome quantification in human influenza infections
PLoS One 11(4): e0153674.
Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF
PLoS One 11(8): e0159878.
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
PLoS One 12(7): e0181468.
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy
PLoS One 13(3): e0194225.
A proteomic signature that reflects pancreatic beta-cell function
PLoS One 13(8): e0202727.
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study
PLoS One 13(12): e0208042.
SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimer's dementia patients
PLoS One. 2019 Feb 14;14(2):e0212261.
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease
PLoS Pathog 13(11): e1006687.
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay
J Appl Lab Med. 2019 Jul;4(1):30-39.
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease
EMBO Mol Med 9(11): 1504-1520.
GDF15 is a heart-derived hormone that regulates body growth
EMBO Mol Med 9(8): 1150-1164.
High-content affinity-based proteomics: unlocking protein biomarker discovery
Expert Rev Mol Diagn 10(8): 1013-1022.
Diagnosis and prognosis-review of biomarkers for mesothelioma
Ann Transl Med 5(11): 244.
Systematic selection of modified aptamer pairs for diagnostic sandwich assays
Biotechniques 56(3): 125-128, 130, 132-133.
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Diabetes Care. 2019 Jul;42(7):1263-1273.
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
J Alzheimers Dis 38(3): 515-531.
Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease
J Alzheimers Dis 49(4): 1105-1114.
Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition
Haematologica 103(3): 466-476.
Clinical validation of a protein biomarker panel for non-small cell lung cancer
J Korean Med Sci 33(53): e342.
Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy
Frontiers in Cardiovascular Medicine 4: 49.
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways
Front Med (Lausanne). 2019; 6: 54.
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance
Front Microbiol. 2019 Mar 26;10:596.
Validation of a novel modified aptamer-based array proteomic platform in patients with end-stage renal disease
Diagnostics (Basel) 8(4).
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
Metabolites 9(7), 122. https://doi.org/10.3390/metabo9070122.
Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array
J Extracell Vesicles 5: 31209.
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Nat Commun 9(1): 3268.
A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations
Am J Clin Nutr 105(2): 343-351.
An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein
Bioanalysis 8(15): 1557-1564.
Protein signature of lung cancer tissues
PLoS One 7(4): e35157.
Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis
J Clin Microbiol 55(10): 3057-3071.
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity
Nature 544(7649): 235-239.
Plasma protein patterns as comprehensive indicators of health
Nat Med. Dec;25(12):1851-1857.
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Sci Rep. 2019 Oct 29;9(1):15449.
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers
Biochemistry. 2019 Nov 19;58(46):4632-4640.
Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics
Clin Transplant. 2019 Dec 9:e13765.
Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma
Front Oncol. 9: 1150.
Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
Viruses 2019, 11(11), 1028.
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
Theranostics. 2019 Aug 22;9(22):6601-6617.
