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Plasma protein patterns as comprehensive indicators of health
Williams SA, et. al.
(2019) Nature Medicine. 25, 1851-1857.
Nature Medicine
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
Zaghlool SB, et. al.
(2020) Nature Communications. 11, Article number: 15
Nature Communications
Undulating changes in human plasma proteome profiles across the lifespan
Lehallier B, et. al.
(2019) Nature Medicine. 25, 1843-1850.
Nature Medicine
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
Shi L, et. al.
(2019) Alzheimers Dement. 5. pii: S1552-5260(19)35118-0
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis.
Grover M, et. al.
(2019) Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152
Immunity Metabolic disease
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Hathout Y, et. al.
(2019) Sci Rep. 2019 Aug 21;9(1):12167
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid.
Simats A, et. al.
(2019) Methods Mol Biol. 2044:221-231
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers.
Hok-A-Hin YS, et. al.
(2019) Methods Mol Biol. 2044:27-50
Neurological SomaScan technology
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation.
Leonard A, et. al.
(2019) J Allergy Clin Immunol Pract. pii: S2213-2198(19)30719-6.
Inflammatory disease
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases.
Deterding RR, et. al.
(2019) Am J Respir Crit Care Med. doi: 10.1164
Pediatric disease Respiratory
A serum protein signature of APOE genotypes in centenarians.
Sebastiani P, et. al.
(2019) Aging Cell. :e13023. doi: 10.1111
Plasma proteome in multiple sclerosis disease progression.
Malekzadeh A, et. al.
(2019) Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.
Tsujikawa LM, et. al.
(2019) Clin Epigenetics. 2019; 11: 102
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy.
Shimada YJ, et. al.
(2019) J Cardiovasc Transl Res. 2019 Dec;12(6):569-579
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome.
Suhre K, et. al.
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass.
Huang G, et. al.
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Gordin D, et. al.
(2019) Diabetes Care. 2019 Jul;42(7):1263-1273
Kidney disease Metabolic-disease
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells.
Zahedi-Amiri A, et. al.
(2019) Cell Death Dis. 2019 May; 10(5): 337
Infectious disease Reproductive-biology
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.
Penn-Nicholson A, et. al.
(2019) PLoS Med. 2019 Apr; 16(4): e1002781
Infectious disease
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.
Mulla CM, et. al.
(2019) Obes Surg. 2019 Jul;29(7):2092-2099
Metabolic disease
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways.
Bar-Or D, et. al.
(2019) Front Med (Lausanne). 2019; 6: 54
Metabolic disease Neurological
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan.
Fong TG, et. al.
(2019) Ann Surg. 2019 Mar 26. doi: 10.1097
Aging Inflammatory disease
Cancer protein biomarker discovery based on nucleic acid aptamers.
Xiong H, et. al.
(2019) Int J Biol Macromol. 2019 Jul 1;132:190-202
A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study.
Helfand BT, et. al.
(2019) Urology. 2019 Jul;129:35-42
Kidney disease
SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimer's dementia patients.
Begic E, et. al.
(2019) PLoS One. 2019 Feb 14;14(2):e0212261
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay.
Tin, A et. al.
(2019) J Appl Lab Med. 2019 Jul;4(1):30-39
Activin type II receptor signaling in cardiac aging and heart failure.
Roh, JD et. al.
(2019) Sci Transl Med 11(482).
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer.
Mysona, D et. al.
(2019) Gynecol Oncol 152(3):574-580.
Human PAH is characterized by a pattern of lipid-related insulin resistance.
Hemnes, AR et. al.
(2019) JCI Insight 4(1).
Metabolic disease Respiratory
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology.
Lynch, AM et. al.
(2019) Transl Vis Sci Technol 8(1): 14
Aging Other disease
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study.
Ko, D et. al.
(2019) J Am Heart Assoc 8(6): e010976
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets.
Bodewes, ILA et. al.
(2019) Front Immunol 10: 312.
Immunity Inflammatory disease
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.
Masvekar, R et. al.
(2018) Mult Scler Relat Disord 28: 34-43
Vero cell proteomic changes induced by Zika virus infection.
Glover, KKM et. al.
(2018) Proteomics 19(4): e1800309
Infectious disease Neurological
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance.
Sher et. al.
(2019) Front Microbiol. 2019 Mar 26;10:596
Infectious disease Neurological
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice.
Desai, VG et. al.
(2019) Toxicol Appl Pharmacol 363:164-173
The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling.
Michelsen, TM et. al.
(2019) FASEB J 33(2):2944-2956
Reproductive biology
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis.
Foulkes, AC et. al.
(2019) J Invest Dermatol 139(1): 100-107
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps.
Wu, D et. al.
(2019) Laryngoscope 129(3): E102-E109
Exosomes Osteoporosis Orthopedics
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide.
Nocera, AL et. al.
(2019) J Allergy Clin Immunol 143(4):1525-1535 e1521
Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps.
Mueller, SK et. al.
(2019) Int Forum Allergy Rhinol 9(2): 177-186
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis.
Liang, X et. al.
(2019) Calcif Tissue Int 104(2): 171-181
Osteoporosis Orthopedics
Probing the virtual proteome to identify novel disease biomarkers.
Mosley, JD et. al.
(2018) Circulation 138(22): 2469-2481
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes.
Halama, A et. al.
(2018) Diabetes Obes Metab., Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111
Metabolic disease
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.
Dubin, RF et. al.
(2018) PLoS One 13(12): e0208042
Cardiovascular Kidney disease
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia.
Giudice, V et. al.
(2018) Exp Hematol 68: 38-50
Rare diseases
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid.
DeBoer, EM et. al.
(2018) Proteomics Clin Appl: e1800085
Rare diseases
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis.
Conklin, LS et. al.
(2018) Steroids 140: 159-166
Inflammatory disease Rare-diseases
Clinical validation of a protein biomarker panel for non-small cell lung cancer.
Jung, YJ et. al.
(2018) J Korean Med Sci 33(53): e342
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.
Santos-Parker, JR et. al.
(2018) J Appl Physiol (1985) 125(5): 1646-1659
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug.
Conklin, LS et. al.
(2018) Pharmacol Res 136: 140-150
A proteomic signature that reflects pancreatic beta-cell function.
Curran, AM et. al.
(2018) PLoS One 13(8): e0202727
Metabolic disease
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation.
Kollar, B et. al.
(2018) Sci Rep 8(1): 14915
Inflammatory disease
Classification of prostate cancer using a protease activity nanosensor library.
Dudani, JS et. al.
(2018) Proc Natl Acad Sci U S A 115(36): 8954-8959
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis.
Rice, LM et. al.
(2018) Arthritis Res Ther 20(1): 185
Cytokines IL-17, TNF and IFN-gamma alter the expression of antimicrobial peptides and proteins disparately: a targeted proteomics analysis using SOMAscan technology.
Altieri, A et. al.
(2018) Vaccines (Basel) 6(3).
Infectious disease
Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps.
Mueller, SK et. al.
(2018) Int Forum Allergy Rhinol 8(12): 1438-1444
Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome.
Patel, V et. al.
(2018) Biomark Res 6: 28
Metabolic disease
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
Yao, C et. al.
(2018) Nat Commun 9(1): 3268
Validation of a novel modified aptamer-based array proteomic platform in patients with end-stage renal disease.
Han, Z et. al.
(2018) Diagnostics (Basel) 8(4).
Kidney disease
Co-regulatory networks of human serum proteins link genetics to disease.
Emilsson, V et. al.
(2018) Science 361(6404): 769-773
Scanning" into the future: the promise of SOMAScan technology for kidney disease.
Coca, SG
(2018) Kidney Int Rep 3(5): 1020-1022
Kidney disease
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients.
Yu, LR et. al.
(2018) Kidney Int Rep 3(5): 1202-1213
Kidney disease
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Tasaki, S et. al.
(2018) Nat Commun 9(1): 2755.
Plasma proteomic signature of age in healthy humans.
Tanaka, T et. al.
(2018) Aging Cell 17(5): e12799
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease.
Pierson, SK et. al.
(2018) Am J Hematol 93(7): 902-912
Inflammatory disease Rare-diseases
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state.
King, JD et. al.
(2018) Cartilage. 2018 Jul 1:1947603518790009
Inflammatory disease
Endothelial microparticles and systemic complement activation in patients with chronic kidney disease.
Jalal, D et. al.
(2018) J Am Heart Assoc 7(14): e007818
Inflammatory disease Kidney-disease
Cerebrospinal fluid protein changes in preeclampsia.
Ciampa, E et. al.
(2018) Hypertension 72(1): 219-226
Reproductive biology
Genomic atlas of the human plasma proteome.
Sun, BB et. al.
(2018) Nature 558: 73-79
SomaScan technology
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform.
Kim, CH et. al.
(2018) Sci Rep 8(1): 8382
SomaScan technology
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells.
Jin, P et. al.
(2018) Cytotherapy 20(5): 728-739
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies.
Spitali, P et. al.
(2018) J Cachexia Sarcopenia Muscle 9(4): 715-726
Muskuloskeletal Pediatric disease
Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study.
Hess, AL et. al.
(2018) Genes Nutr 13: 7
Metabolic disease
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Simats, A et. al.
(2018) Sci Rep 8(1): 7899
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome.
Depner CM et. al.
(2018) Proc Natl Acad Sci U S A 115(23): E5390-E5399
Metabolic disease
Harnessing the power of proteomics to assess drug safety and guide clinical trials.
Lam, MPY et. al.
(2018) Circulation 137(10): 1011-1014
Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib.
Williams, SA et. al.
(2018) Circulation 137(10): 999-1010
Integrative omics: harnessing the proteome to maximize the potential of the genome.
McGarrah, RW et. al.
(2018) Circulation 137(11): 1173-1175
Genetic architecture of the cardiovascular risk proteome.
Benson, MD et. al.
(2018) Circulation 137(11): 1158-1172
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy.
Parolo, S et. al.
(2018) PLoS One 13(3): e0194225
Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition.
Wang, X et. al.
(2018) Haematologica 103(3): 466-476
Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis.
Zhang, W et. al.
(2018) Cell Mol Immunol 15(8): 756-767
The impact of the glomerular filtration rate on the human plasma proteome.
Christensson, A et. al.
(2018) Proteomics Clin Appl 12(3): e1700067
Kidney disease
Benefit of apabetalone on plasma proteins in renal disease.
Wasiak, S et. al.
(2018) Kidney International Reports 3(3): 711-721
Kidney disease
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
Zaghlool, SB et. al.
(2018) Hum Mol Genet 27(6): 1106-1121
Metabolic disease Respiratory
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism.
Thrush, AB et. al.
(2018) Int J Obes (Lond) 42(3): 353-362
Metabolic disease Osteoporosis-Orthopedics
Serum proteomic assessment of the progression of fracture healing.
Hussein, AI et. al.
(2018) J Orthop Res 36(4): 1153-1163
Osteoporosis Orthopedics
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
Vilar-Gomez, E et. al.
(2018) J Hepatol 68(2): 305-315.
Fibrotic Disease Inflammatory-disease Metabolic-disease
The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention.
Oller Moreno, S et. al.
(2018) Proteomics Clin Appl 12(1).
Metabolic disease
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening.
Forster, K et. al.
(2018) Am J Respir Crit Care Med 197(8): 1076-1080
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis.
Wermuth, PJ et. al.
(2018) Rheumatology (Oxford) 57(10): 1698-1706
Application of large scale aptamer-based proteomic profiling to "planned myocardial infarctions.
Jacob, J et. al.
(2018) Circulation 137(12): 1270-1277.
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma.
Rossios, C et. al.
(2018) J Allergy Clin Immunol 141(2): 560-570.
Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging.
Strauss, S et. al.
(2018) Nat Methods 15(9): 685-688
SomaScan technology
Improving probes for super-resolution.
Moore, RP et. al.
(2018) Nat Methods 15(9): 659-660
SomaScan technology
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents.
Katilius E et. al.
(2018) Forensic Sci Int Genet 35: 9-13
SomaScan technology
Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples.
Duo J et. al.
(2018) Anal Chem 90(8): 5162-5170
Oncology SomaScan technology
The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes.
O'Dwyer, DN et. al.
(2017) Sci Rep 7: 46560.
Fibrotic Disease Respiratory
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.
Oak, P et. al.
(2017) EMBO Mol Med 9(11): 1504-1520.
Molecular-based diagnosis of multiple sclerosis and its progressive stage.
Barbour, C et. al.
(2017) Ann Neurol 82(5): 795-812.
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator.
Carayol, J et. al.
(2017) Nat Commun 8(1): 2084
Metabolic disease
A pilot characterization of the human chronobiome.
Skarke, C et. al.
(2017) Sci Rep 7(1):17141.
Metabolic disease
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study.
Romero, R et. al.
(2017) Am J Obstet Gynecol 217(1):67 e61-67 e21.
Reproductive biology
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.
Spitsin, S et. al.
(2017) JCI Insight. 2017 Oct 5;2(19). pii: 95893
Immunity Infectious disease
Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures.
Curran, AM et. al.
(2017) J Proteome Res 16(11): 4122-4133.
Aging Metabolic disease
Vitamin B12 deficiency and impaired expression of amnionless during aging.
Pannerec, A et. al.
(2017) J Cachexia Sarcopenia Muscle 9(1): 41-52.
A degradation fragment of type X collagen is a real-time marker for bone growth velocity.
Coghlan, RF et. al.
(2017) Sci Transl Med 9(419): eaan4669.
Osteoporosis Orthopedics
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation.
Sullivan, KD et. al.
(2017) Sci Rep 7(1): 14818.
Rare diseases
Assessment of variability in the SOMAscan assay.
Candia, J et. al.
(2017) Sci Rep 7(1):14248.
SomaScan technology
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.
Scriba, TJ et. al.
(2017) PLoS Pathog 13(11): e1006687.
Infectious disease
Divergent roles for clusterin in lung injury and repair.
Habiel, DM et. al.
(2017) Sci Rep 7(1): 15444.
Fibrotic Disease Respiratory
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia.
Lertudomphonwanit, C et. al.
(2017) Sci Transl Med 9(417): eaan8462
Pediatric disease
Potential of high-affinity, Slow Off-Rate Modified Aptamer (SOMAmer) reagents for Mycobacterium tuberculosis proteins as tools for infection models and diagnostic applications.
Russell, T et. al.
(2017) J Clin Microbiol 55(10): 3072-3088
Infectious disease
Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis.
De Groote, MA et. al.
(2017) J Clin Microbiol 55(10): 3057-3071.
Infectious disease
Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy.
Anderson, J et. al.
(2017) Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular Neurological Pediatric disease
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial.
Ali A et. al.
(2017) BMJ Open Gastro 4(1): e000164.
Inflammatory disease
Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants.
Wagner, BD et. al.
(2017) Am J Respir Crit Care Med 197(3): 394-397
Cardiovascular Pediatric disease
Identification of unique proteomic signatures in allergic and non-allergic skin disease.
Wang, J et. al.
(2017) Clin Exp Allergy 47(11): 1456-1467
Inflammatory disease
An immune clock of human pregnancy.
Aghaeepour, N et. al.
(2017) Sci Immunol 2(15):eaan2946.
Immunity Reproductive biology
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.
Rhodes, CJ et. al.
(2017) Lancet Respir Med 5(9): 717-726
Cardiovascular Rare diseases Respiratory
Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk.
Belongie, KJ et. al.
(2017) PLoS One 12(8): e0182932.
Metabolic disease
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study.
Erez, O et. al.
(2017) PLoS One 12(7): e0181468.
Reproductive biology
Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy.
Fitzgibbons, TP et. al.
(2017) Frontiers in Cardiovascular Medicine 4: 49.
Diagnosis and prognosis-review of biomarkers for mesothelioma.
Sun, HH et. al.
(2017) Ann Transl Med 5(11): 244.
Downregulation of the complement cascade in vitro, in mice and in patients with cardiovascular disease by the BET protein inhibitor apabetalone (RVX-208).
Wasiak, S et. al.
(2017) J Cardiovasc Transl Res, 10(4): 337-347.
Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis.
DeBoer, EM et. al.
(2017) Proteomics Clin Appl 11(9-10).
Pediatric disease Respiratory
GDF15 is a heart-derived hormone that regulates body growth.
Wang, T et. al.
(2017) EMBO Mol Med 9(8): 1150-1164
Cardiovascular Pediatric disease
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Howson, JMM et. al.
(2017) Nat Genet 49(7): 1113-1119.
Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome.
Tasaki, S et. al.
(2017) Ann Rheum Dis 76(8): 1458-1466.
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology.
Westwood, S et. al.
(2017) Alzheimers Res Ther 9(1): 31.
Aging Metabolic disease
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.
Saleheen, D et. al.
(2017) Nature 544(7649): 235-239.
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.
Asai, A et. al.
(2017) Development 144(6): 1056-1064.
Development and characterization of an HPV Type-16 specific modified DNA aptamer for the improvement of potency assays.
Trausch, JJ et. al.
(2017) Anal Chem 89(6): 3554-3561.
Infectious disease
A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains.
Wood, GC et. al.
(2017) Sci Rep 7: 43238.
Metabolic disease
Identification of serum protein biomarkers for utrophin based DMD therapy.
Guiraud, S et. al.
(2017) Sci Rep 7: 43697.
Muskuloskeletal Pediatric disease
Connecting genetic risk to disease end points through the human blood plasma proteome.
Suhre, K et. al.
(2017) Nat Commun 8: 14357.
SomaScan technology
Selection of aptamers to Neisseria meningitidis and Streptococcus pneumoniae surface specific proteins and affinity assay using thin film AlN resonators.
Escolano, JM et. al.
(2017) Sensors and Actuators B: Chemical 246: 591-596.
Infectious disease
The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility.
van den Broek, TJ et. al.
(2017) Genes Nutr 12: 5.
Metabolic disease
High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors.
Di Narzo, AF et. al.
(2017) PLoS Genet 13(1): e1006565
Aging Inflammatory disease
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome.
Sasayama, D et. al.
(2017) Hum Mol Genet 26(1): 44-51.
Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea.
Jung, YJ et. al.
(2017) Clin Lung Cancer 18(2): e99-e107.
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform.
Qiao, Z et. al.
(2017) Biochim Biophys Acta 1865(4): 434-443.
A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations.
Zyba, SJ et. al.
(2017) Am J Clin Nutr 105(2): 343-351.
Metabolic disease
A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin.
Rice, LM et. al.
(2017) J Invest Dermatol 137(1): 62-70.
Highly multiplexed proteomic analysis of quantiferon supernatants to identify biomarkers of latent tuberculosis infection.
De Groote, MA et. al.
(2017) J Clin Microbiol 55(2): 391-402.
Infectious disease
Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells.
Billing, AM et. al.
(2017) J Proteomics 150: 86-97
Pharmacokinetic properties of DNA aptamers with base modifications.
Gupta, S et. al.
(2017) Nucleic Acid Ther 27(6): 345-353.
SomaScan technology
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.
Ren, X et. al.
(2017) Nat Commun 8(1): 810.
SomaScan technology
Selection of DNA aptamers with two modified bases.
Gawande, BN et. al.
(2017) Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan technology
Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease.
Heier, CR et. al.
(2016) Clin Transl Gastroenterol 7(9): e192.
Inflammatory disease Pediatric-disease
Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma (DIAPHRAGM) study: protocol of a prospective, multicentre, observational study.
Tsim, S et. al.
(2016) BMJ Open 6(11): e013324.
The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity.
Lynch, AM et. al.
(2016) Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Pediatric disease
Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF.
Ashley, SL et. al.
(2016) PLoS One 11(8): e0159878.
Fibrotic Disease Respiratory
Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array.
Welton, JL et. al.
(2016) J Extracell Vesicles 5: 31209.
Exosomes Oncology
Incorporation of Slow Off-Rate Modified Aptamers reagents in single molecule array assays for cytokine detection with ultrahigh sensitivity.
Wu, D et. al.
(2016) Anal Chem 88(17): 8385-8389.
SomaScan technology
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children.
Hathout, Y et. al.
(2016) Sci Rep 6: 31727.
Inflammatory disease Pediatric-disease
Identifying low-abundance biomarkers: Aptamer-based proteomics potentially enables more sensitive detection in cardiovascular diseases.
Gramolini, A et. al.
(2016) Circulation 134(4): 286-289.
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease.
Ngo, D et. al.
(2016) Circulation 134(4): 270-285
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction.
Sabatine, MS
(2016) JAMA 315(23): 2525-2526.
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease.
Ganz, P et. al.
(2016) JAMA 315(23): 2532-2541
An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein.
Gupta, V et. al.
(2016) Bioanalysis 8(15): 1557-1564.
SomaScan technology
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
Lukjanenko, L et. al.
(2016) Nat Med 22(8): 897-905.
Aging Muskuloskeletal
A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD).
Petek, LM et. al.
(2016) Neuromuscul Disord 26(7): 405-413
Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome.
Nishikawa, A et. al.
(2016) Arthritis Res Ther 18(1): 106.
Respiratory mucosal proteome quantification in human influenza infections.
Marion, T et. al.
(2016) PLoS One 11(4): e0153674.
Infectious disease
Fit for the eye: aptamers in ocular disorders.
Drolet, DW et. al.
(2016) Nucleic Acid Ther 26(3): 127-146.
Other disease
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Murota, A et. al.
(2016) Cytokine 78: 87-93.
Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease.
Sattlecker, M et. al.
(2016) J Alzheimers Dis 49(4): 1105-1114.
Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys.
Hirota, M et. al.
(2016) Nucleic Acid Ther 26(1): 10-19.
The relationship of circulating proteins in early pregnancy with preterm birth.
Lynch, AM et. al.
(2016) Am J Obstet Gynecol 214(4): 517 e511-518.
Reproductive biology
Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery.
McArdle, A et. al.
(2016) Proteomics Clin Appl 10(6): 691-698.
readat: an R package for reading and working with SomaLogic ADAT files.
Cotton, RJ et. al.
(2016) BMC Bioinformatics 17(1): 201.
Embracing proteins: structural themes in aptamer-protein complexes.
Gelinas, AD et. al.
(2016) Curr Opin Struct Biol 36: 122-132.
SomaScan technology
Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts.
Olson, KA et. al.
(2015) Eur Heart J 36(48): 3426-3434.
Aging Cardiovascular
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.
Kiddle, SJ et. al.
(2015) Transl Psychiatry 5: e584.
Increased cerebrospinal fluid fibrinogen in major depressive disorder.
Hattori, K et. al.
(2015) Sci Rep 5: 11412.
Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy.
Hathout, Y et. al.
(2015) Proc Natl Acad Sci U S A 112(23): 7153-7158.
Muskuloskeletal Pediatric disease
Circulating proteomic signatures of chronological age.
Menni, C et. al.
(2015) J Gerontol A Biol Sci Med Sci 70(7): 809-816.
SELEX: How it happened and where it will go.
Gold, L
(2015) J Mol Evol 81(5-6): 140-143.
Improved preparation of 2 M triethylammonium bicarbonate.
Carlson, M et. al.
(2015) Green Chem Lett Rev 8(3-4): 37-39.
SomaScan technology
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides.
Wolk, SK et. al.
(2015) Nucleic Acids Res 43(19): 9107-9122.
SomaScan technology
Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor.
Jarvis, TC et. al.
(2015) Structure 23(7): 1293-1304.
SomaScan technology
Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents.
Rohloff, JC et. al.
(2015) Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
SomaScan technology
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
Motzer, RJ et. al.
(2014) Cancer Chemother Pharmacol 74(4): 739-750.
Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents.
Rohloff, JC et. al.
(2014) Mol Ther Nucleic Acids 3:e201.
SomaScan technology
Validation of a blood protein signature for non-small cell lung cancer.
Mehan, MR et. al.
(2014) Clin Proteomics 11(1): 32.
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components.
Baumstummler, A et. al.
(2014) Lett Appl Microbiol 59(4): 422-431.
Infectious disease
Genetic associations with micronutrient levels identified in immune and gastrointestinal networks.
Morine, MJ et. al.
(2014) Genes Nutr 9(4): 408
Metabolic disease
Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study.
Monteiro, JP et. al.
(2014) Genes Nutr 9(3): 403.
Metabolic disease
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.
Sattlecker, M et. al.
(2014) Alzheimers Dement 10(6): 724-734.
Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis.
Nahid, P et. al.
(2014) Tuberculosis (Edinb) 94(3): 187-196.
Infectious disease
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.
Webber, J et. al.
(2014) Mol Cell Proteomics 13(4): 1050-1064.
Exosomes Oncology
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study.
Kiddle, SJ et. al.
(2014) J Alzheimers Dis 38(3): 515-531.
Systematic selection of modified aptamer pairs for diagnostic sandwich assays.
Ochsner, UA et. al.
(2014) Biotechniques 56(3): 125-128, 130, 132-133.
Cardiovascular Infectious disease SomaScan-technology
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.
Gelinas, AD et. al.
(2014) J Biol Chem 289(12): 8720-8734.
SomaScan technology
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.
Gupta, S et. al.
(2014) J Biol Chem 289(12): 8706-8719.
SomaScan technology
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers.
Ochsner, UA et. al.
(2013) Diagn Microbiol Infect Dis 76(3): 278-285
Infectious disease
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin.
Xie, Y et. al.
(2013) EMBO Rep 14(12): 1120-1126.
Oncology SomaScan technology
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.
Loffredo, FS et. al.
(2013) Cell 153(4): 828-839.
Measurement of cetuximab and panitumumab-unbound serum EGFR extracellular domain using an assay based on slow off-rate modified aptamer (SOMAmer) reagents.
Park, NJ et. al.
(2013) PLoS One 8(8): e71703.
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment.
De Groote, MA et. al.
(2013) PLoS One 8(4): e61002.
Infectious disease
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool.
Ostroff, RM et. al.
(2012) PLoS One 7(10):e46091.
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array.
Baird, GS et. al.
(2012) Am J Pathol 180(2): 446-456.
Aging Neurological
Protein signature of lung cancer tissues.
Mehan, MR et. al.
(2012) PLoS One 7(4): e35157.
Life's simple measures: unlocking the proteome.
Brody, E et. al.
(2012) J Mol Biol 422(5):595-606.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Davies, DR et. al.
(2012) Proc Natl Acad Sci U S A 109(49): 19971-19976
SomaScan technology
Aptamers and the RNA world, past and present.
Gold, L et. al.
(2012) Cold Spring Harb Perspect Biol 4(3).
Rapid histochemistry using slow off-rate modified aptamers with anionic competition.
Gupta, S et. al.
(2011) Appl Immunohistochem Mol Morphol 19(3): 273-278.
SomaScan technology
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay.
Kraemer, S et. al.
(2011) PLoS One 6(10): e26332.
SomaScan technology
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.
Ostroff, RM et. al.
(2010) PLoS One 5(12): e15003.
High-content affinity-based proteomics: unlocking protein biomarker discovery.
Brody, EN et. al.
(2010) Expert Rev Mol Diagn 10(8): 1013-1022.
Expanding the chemistry of DNA for in vitro selection.
Vaught, JD et. al.
(2010) J Am Chem Soc 132(12): 4141-4151.
SomaScan technology
Aptamer-based multiplexed proteomic technology for biomarker discovery.
Gold, L et. al.
(2010) PLoS One 5(12): e15004.
Proteomics and diagnostics: Let's get specific, again.
Zichi, D et. al.
(2008) Curr Opin Chem Biol 12(1): 78-85.
SomaScan technology
Let's get specific: the relationship between specificity and affinity.
Eaton, BE et. al.
(1995) Chem Biol 2(10): 633-638.
SomaScan technology
High-resolution molecular discrimination by RNA.
Jenison, RD et. al.
(1994) Science 263(5152): 1425-1429.
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA.
Zimmermann, GR et. al.
(1997) Nat Struct Biol 4(8): 644-649.
SomaScan technology