mission

To promote collaboration among cohort studies that use SomaScan profiling to follow participants for a range of outcomes

The Consortium exists to promote collaboration among prospective cohort studies that follow participants for a range of outcomes and perform SomaScan profiling of individuals. We will provide the framework to foster international collaborations among studies sharing common objectives, including a forum for the discussion, development and pursuit of new collaborative studies and research directions. We will facilitate an open exchange of ideas, knowledge, and results in order to accelerate the study of proteomics profiles associated with chronic disease phenotypes.

Additional Consortium principles

  • Store datasets locally, not in a repository
  • Promote result sharing
  • Adopt a distributive analysis model
  • Support the development of early career researchers
  • Advance the knowledge of the proteome to improve our understanding of prediction of disease etiology, diagnosis and prognosis
  • Raise common funds through grants and donations by sharing analyses and preliminary data
  • Create a harmonized proteomic resource that bridges platforms for more powerful association analyses

Initial Consortium cohorts

Cohort Acronym Population Website Contact
COPDGene
US Older Current and Formers Smokers

Russell Bowler

BowlerR@njhealth.org

SPIROMICS
US Older Current and Formers Smokers

Russell Bowler

BowlerR@njhealth.org

FHS
US New England Population
JHS
US Mississippi AA Population
MESA
US Multi-Ethnic Population

Ani Manichaikul

amanicha@virginia.edu

LSC
US SW Community Cohort

current and former smokers
No website

Yohannes Tesfaigzi

ytesfaigzi@bwh.harvard.edu

KORA
Southern Germany Population

Get in touch

For general inquries, contact Russ Bowler BowlerR@njhealth.org

Updates

September 15 meeting: Daryl Perry of SomaLogic led a discussion on data normalization

From the SomaLogic team:

“Thanks everyone for a really great discussion on the different types of controls and the importance of each in normalization. The Bioinformatics Team is always happy to talk more about any of the topics we covered.”

In light of the current pandemic, the SomaScan Proteomics Consortium will be initially focused on the exchange of information relevant to COVID-19

Update from Ani Manichaikul:

“We are performing a genome-wide association study of ACE2 levels measured by SomaScan to identify the genetic variants and pathways that modulate ACE2 levels. Our project combines SOMAscan data from multiple cohorts including the Multi-Ethnic Study of Atherosclerosis (MESA), the Genetic Epidemiology of COPD (COPDGene) study, and the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), among others.”